SMOC2

Across TCGA patient cohorts, SMOC2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMOC2-associated genes across cancer lineages are STAT3_pY705, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with SMOC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMOC2-to-partner and partner-to-SMOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SMOC2-low versus SMOC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMOC2→partner) and Y-score (partner→SMOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.422	-2.000	<.001	.032	3	2
UCEC	Caspase-7-cleavedD198 →	+0.846	+3.341	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.303	-2.000	.007	.032	3	1
UCEC	eIF4E →	+0.207	+3.169	.029	.019	3	1
UCEC	FoxM1 →	+0.233	+2.000	.046	.032	3	1
UCEC	p62 Lck ligand →	+0.499	+2.000	<.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

STAT3_pY705 by SMOC2 expression — UCEC

Explore this box plot interactively →