SMOC2

Across TCGA cell cohorts, SMOC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,104 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SMOC2-associated GO terms across cancer lineages are Positive regulation of vascular wound healing, Mitochondrion organization, and Regulation of coagulation. Each is linked with SMOC2 in more than 7 cancer types. Because this analysis shows association rather than direction, both SMOC2-to-partner and partner-to-SMOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of vascular wound healing grouped by SMOC2-low versus SMOC2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMOC2→partner) and Y-score (partner→SMOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of vascular wound healing →	-0.192	-1.478	.001	<.001	3	8
LUNG_NSCLC_LUSC	Mitochondrion organization →	+0.044	+1.743	.009	.002	3	7
BREAST	Regulation of coagulation →	-0.146	-1.576	<.001	.002	3	6
BONE	Aerobic electron transport chain →	+0.079	+1.023	<.001	.009	3	6
BONE	Electron transport chain →	+0.086	+1.372	<.001	.005	3	6
BONE	Positive regulation of ERK1 and ERK2 cascade →	-0.085	-1.300	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,104 associations by consensus.

Positive regulation of vascular wound healing by SMOC2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →