SMOC2

Across TCGA cell cohorts, SMOC2 mutation is significantly associated with the drug of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMOC2-associated genes across cancer lineages are Leflunomide, RVX-208, and 50869. Each is linked with SMOC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMOC2-to-partner and partner-to-SMOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Leflunomide grouped by SMOC2-low versus SMOC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMOC2→partner) and Y-score (partner→SMOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Leflunomide →	+0.256	+2.769	.046	.040	3	1
LARGE_INTESTINE	RVX-208 →	+0.409	+2.646	.007	.047	3	1
LARGE_INTESTINE	50869 →	+0.506	+2.710	.016	.027	3	1
LARGE_INTESTINE	150412 →	+0.389	+2.777	.020	.038	3	1
LARGE_INTESTINE	Tivozanib →	+0.240	+2.786	.034	.037	3	1
LARGE_INTESTINE	kb NB 142-70 →	+0.629	+2.652	.006	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Leflunomide by SMOC2 expression — LARGE_INTESTINE

Explore this box plot interactively →