Across TCGA pan-cancer cohorts, SMOC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMOC1 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SMOC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMOC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where SMOC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.254	0.854	.008	42	view →
UCEC	DFS	Median	III,IV	0.380	1.000	.003	24	view →
LSCC	DFS	Quartile	All	0.836	0.978	.009	14	view →
PDAC	OS	Median	III,IV	0.228	0.653	.008	11	view →
CCRCC	DFS	Median	III,IV	1.000	0.809	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SMOC1 tumor-vs-normal RNA expression · all SMOC1 data types