Across TCGA patient cohorts, SMOC1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMOC1-associated genes across cancer lineages are Notch1, Caspase-8, and STAT5a. Each is linked with SMOC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMOC1-to-partner and partner-to-SMOC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMOC1→partner) and Y-score (partner→SMOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.155	+2.179	.014	.034	3	3
SKCM	Caspase-8 →	-0.224	-2.222	<.001	.010	3	2
SKCM	STAT5a →	+0.547	+3.186	.019	.009	3	1
UCEC	EGFR_pY1068 →	-0.247	-2.000	.029	.032	3	1
UCEC	ERK2 →	+0.284	+2.700	.001	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-2.687	.013	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

SMOC1 survival (RNA) · tumor vs normal (RNA) · all SMOC1 data types