SMO

Across TCGA patient cohorts, SMO mutation is significantly associated with the RNA expression of many other genes, with 4,515 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMO-associated genes across cancer lineages are COX15, TYW3, and MAIP1. Each is linked with SMO in more than 2 cancer types. Because this analysis shows association rather than direction, both SMO-to-partner and partner-to-SMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by SMO-low versus SMO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMO→partner) and Y-score (partner→SMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.535	+2.392	<.001	<.001	3	3
UCEC	TYW3 →	+0.479	+2.628	<.001	.005	3	3
UCEC	MAIP1 →	+0.471	+3.119	.002	<.001	3	3
UCEC	PAQR3 →	+0.606	+2.456	<.001	<.001	3	3
UCEC	NAA15 →	+0.564	+3.732	<.001	<.001	3	3
UCEC	PRDX3 →	+0.533	+3.732	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,515 associations by consensus.

COX15 by SMO expression — UCEC

Explore this box plot interactively →