SMO

Across TCGA patient cohorts, SMO mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMO-associated genes across cancer lineages are PCNA, Cyclin-B1, and FOXO3a_pS318_S321. Each is linked with SMO in more than 3 cancer types. Because this analysis shows association rather than direction, both SMO-to-partner and partner-to-SMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SMO-low versus SMO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMO→partner) and Y-score (partner→SMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.222	+2.087	.007	.005	3	3
STAD	Cyclin-B1 →	+0.572	+3.000	.017	.036	1	4
UCEC	FOXO3a_pS318_S321 →	-0.098	-1.690	.041	.042	3	2
UCEC	4E-BP1 →	+0.357	+3.489	<.001	.002	3	2
UCEC	eIF4E →	+0.209	+3.335	.009	.005	3	1
UCEC	ERK2 →	+0.179	+2.115	.015	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PCNA by SMO expression — UCEC

Explore this box plot interactively →