SMO

Across TCGA cell cohorts, SMO RNA expression is significantly associated with the go_rna of many other GO terms, with 5,486 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SMO-associated GO terms across cancer lineages are Renal vesicle formation, Metanephric renal vesicle formation, and Ventral midline development. Each is linked with SMO in more than 19 cancer types. Because this analysis shows association rather than direction, both SMO-to-partner and partner-to-SMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Renal vesicle formation grouped by SMO-low versus SMO-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMO→partner) and Y-score (partner→SMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Renal vesicle formation →	+1.884	+3.062	<.001	<.001	3	20
URINARY_TRACT	Metanephric renal vesicle formation →	+1.884	+3.062	<.001	<.001	3	20
BREAST	Ventral midline development →	+1.498	+3.033	<.001	<.001	3	20
BONE	Lipoprotein transport →	+0.193	+1.697	<.001	<.001	3	14
BONE	Positive regulation of DNA repair →	+0.091	+1.750	<.001	<.001	3	14
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.128	+2.352	.007	<.001	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,486 associations by consensus.

Renal vesicle formation by SMO expression — URINARY_TRACT

Explore this box plot interactively →