SMO

Across TCGA cell cohorts, SMO mutation is significantly associated with the RNA expression of many other genes, with 666 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMO-associated genes across cancer lineages are MYMK, KRTAP9-9, and KLK15. Each is linked with SMO in more than 1 cancer types. Because this analysis shows association rather than direction, both SMO-to-partner and partner-to-SMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYMK grouped by SMO-low versus SMO-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMO→partner) and Y-score (partner→SMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MYMK →	+0.024	+3.510	<.001	.007	3	2
LUNG_NSCLC_LUAD	KRTAP9-9 →	+0.007	+3.681	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	KLK15 →	+0.079	+3.688	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	PROP1 →	+0.019	+3.510	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	ELOA2 →	+0.102	+4.485	<.001	<.001	3	2
STOMACH	VN1R3 →	+0.020	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 666 associations by consensus.

MYMK by SMO expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →