SMNDC1

Across TCGA cell cohorts, SMNDC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,057 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMNDC1-associated GO terms across cancer lineages are Regulation of sister chromatid cohesion, DNA replication, and Viral translational termination-reinitiation. Each is linked with SMNDC1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SMNDC1-to-partner and partner-to-SMNDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of sister chromatid cohesion grouped by SMNDC1-low versus SMNDC1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMNDC1→partner) and Y-score (partner→SMNDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of sister chromatid cohesion →	+0.155	+0.621	<.001	<.001	3	15
LARGE_INTESTINE	DNA replication →	+0.077	+0.624	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.103	+0.610	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Spindle elongation →	+0.235	+0.622	.004	.006	3	14
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.059	+0.629	.008	.006	3	13
BREAST	Mitotic nuclear division →	+0.078	+0.495	.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,057 associations by consensus.

Regulation of sister chromatid cohesion by SMNDC1 expression — LUNG_NSCLC_LUSC

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