Across TCGA pan-cancer cohorts, SMN2 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SMN2 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SMN2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SMN2 expression acts as an unfavorable survival marker.

BLCA are the cancer types where SMN2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.212	0.720	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SMN2 tumor-vs-normal RNA expression · all SMN2 data types