Across TCGA cell cohorts, SMN2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,977 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SMN2-associated genes across cancer lineages are SMN1, E2F6, and MAD2L1. Each is linked with SMN2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SMN2-to-partner and partner-to-SMN2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMN2→partner) and Y-score (partner→SMN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMN1 →	+0.967	+0.783	.001	.008	3	7
BLOOD_Lymphoma	E2F6 →	+0.763	+0.697	.003	.002	3	6
UPPER_AERODIGESTIVE_TRACT	MAD2L1 →	+1.111	+1.391	<.001	.002	3	5
OVARY	SERF1B →	+1.045	+0.783	.002	.001	3	5
OVARY	GTF2H2C →	+1.376	+0.925	<.001	.002	3	5
LUNG_SCLC	UTP15 →	+0.670	+0.578	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,977 associations by consensus.

Exploration

SMN2 survival (RNA) · tumor vs normal (RNA) · all SMN2 data types