SMN1

Across TCGA cell cohorts, SMN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,150 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMN1-associated GO terms across cancer lineages are Positive regulation of rRNA processing, DNA replication initiation, and Kinetochore organization. Each is linked with SMN1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SMN1-to-partner and partner-to-SMN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of rRNA processing grouped by SMN1-low versus SMN1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMN1→partner) and Y-score (partner→SMN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of rRNA processing →	+0.135	+0.682	<.001	.008	3	16
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.127	+0.728	.001	<.001	3	14
SOFT_TISSUE	Kinetochore organization →	+0.124	+0.442	.001	.002	3	12
SOFT_TISSUE	Double-strand break repair →	+0.076	+0.405	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Regulation of transcription by RNA polymerase III →	+0.058	+0.479	<.001	.004	3	12
STOMACH	Attachment of spindle microtubules to kinetochore →	+0.085	+0.488	<.001	.006	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,150 associations by consensus.

Positive regulation of rRNA processing by SMN1 expression — OESOPHAGUS

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