Across TCGA pan-cancer cohorts, SMIM9 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SMIM9 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SMIM9 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMIM9 expression acts as an unfavorable survival marker, although some lineages such as LIHC and BLCA show a favorable association.

LUSC, KIRP, and LGG are the cancer types where SMIM9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	III,IV	0.351	0.680	.003	45	view →
KIRP	OS	Quartile	II,III,IV	0.121	0.792	<.001	36	view →
LGG	DFS	Tertile	All	0.254	0.443	<.001	30	view →
ACC	OS	Tertile	III,IV	0.594	0.816	.036	27	view →
UVM	OS	Tertile	II,III,IV	0.364	0.667	.039	24	view →
HNSC	DFS	Tertile	III,IV	0.526	0.679	.014	21	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
UCEC	DFS	Tertile	All	0.580	0.669	.013	18	view →
LIHC	DFS	Tertile	All	0.580	0.361	.020	17	view →
BLCA	OS	Tertile	All	0.564	0.401	.038	12	view →
BRCA	DFS	Quartile	All	0.570	1.000	.045	12	view →
MESO	OS	Tertile	IV	0.203	0.661	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

Exploration

Same gene, other analysis: SMIM9 tumor-vs-normal RNA expression · all SMIM9 data types