Across TCGA patient cohorts, SMIM5 protein abundance is significantly associated with the RNA expression of many other genes, with 244 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SMIM5-associated genes across cancer lineages are COBL, P2RX3, and NECTIN1. Each is linked with SMIM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM5-to-partner and partner-to-SMIM5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM5→partner) and Y-score (partner→SMIM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COBL →	+0.703	+0.536	<.001	.007	3	1
CCRCC	P2RX3 →	-0.095	-0.437	.009	.005	3	1
CCRCC	NECTIN1 →	-0.745	-0.437	.008	.005	3	1
CCRCC	ATAT1 →	-0.340	-0.437	.002	.005	3	1
CCRCC	SLC38A4 →	+0.929	+0.437	<.001	.005	3	1
CCRCC	ZNF710 →	-0.649	-0.437	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 244 associations by consensus.

Exploration

SMIM5 survival (RNA) · tumor vs normal (RNA) · all SMIM5 data types