SMIM43

Across TCGA patient cohorts, SMIM43 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM43-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with SMIM43 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM43-to-partner and partner-to-SMIM43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SMIM43-low versus SMIM43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM43→partner) and Y-score (partner→SMIM43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.207	+2.817	.005	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.711	-3.000	.002	.036	3	1
UCEC	PDCD4 →	-0.618	-3.321	.012	.010	3	1
UCEC	Shc_pY317 →	-0.221	-3.321	.005	.010	3	1
UCEC	TIGAR →	+0.240	+3.348	.002	.005	3	1
UCEC	Bax →	+0.340	+2.999	.006	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by SMIM43 expression — UCEC

Explore this box plot interactively →