SMIM43

Across TCGA cell cohorts, SMIM43 RNA expression is significantly associated with the go_rna of many other GO terms, with 980 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMIM43-associated GO terms across cancer lineages are Regulation of transcription elongation by RNA polymerase II, Response to acid chemical, and Cytoplasmic translation. Each is linked with SMIM43 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMIM43-to-partner and partner-to-SMIM43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription elongation by RNA polymerase II grouped by SMIM43-low versus SMIM43-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM43→partner) and Y-score (partner→SMIM43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of transcription elongation by RNA polymerase II →	+0.034	+0.181	.002	.005	3	6
OVARY	Response to acid chemical →	+0.056	+0.509	<.001	.003	3	5
OVARY	Cytoplasmic translation →	+0.100	+0.642	<.001	.006	3	5
OVARY	Cellular component disassembly →	+0.031	+0.663	<.001	.007	3	5
LUNG_NSCLC_LUAD	Viral life cycle →	+0.036	+0.561	<.001	.008	3	5
LUNG_NSCLC_LUAD	RNA catabolic process →	+0.024	+0.666	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 980 associations by consensus.

Regulation of transcription elongation by RNA polymerase II by SMIM43 expression — CNS

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