SMIM4

Across TCGA pan-cancer cohorts, SMIM4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SMIM4 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SMIM4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMIM4 expression acts as an unfavorable survival marker.

UCEC, LUAD, and LSCC are the cancer types where SMIM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.746	1.000	.022	8	view →
LUAD	DFS	Median	All	0.651	1.000	.038	6	view →
LSCC	DFS	Median	All	0.736	0.997	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SMIM4–UCEC (DFS)

Open the UCEC breakdown →