SMIM4

Across TCGA patient cohorts, SMIM4 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,507 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SMIM4-associated proteins across cancer lineages are PAXBP1, PBRM1_S1453, and RASGRP2. Each is linked with SMIM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMIM4-to-partner and partner-to-SMIM4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMIM4 versus PAXBP1 in HNSC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM4→partner) and Y-score (partner→SMIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PAXBP1 →	+0.209	+0.595	<.001	<.001	3	4
CCRCC	PBRM1_S1453 →	+0.833	+0.269	<.001	.004	3	4
OV	RASGRP2 →	-0.401	-0.513	.002	.005	3	4
GBM	TASOR →	+0.228	+0.398	<.001	<.001	3	4
HNSC	TNKS1BP1_S1073 →	-0.529	-0.517	<.001	<.001	3	4
COAD	LRBA_S2496 →	-0.424	-0.386	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,507 associations by consensus.

SMIM4 vs PAXBP1 — HNSC

Explore this scatter interactively →