SMIM4

Across TCGA cell cohorts, SMIM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,410 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SMIM4-associated GO terms across cancer lineages are Mitochondrial proton-transporting ATP synthase complex assembly, Proton-transporting ATP synthase complex assembly, and Fatty acid derivative catabolic process. Each is linked with SMIM4 in more than 8 cancer types. Because this analysis shows association rather than direction, both SMIM4-to-partner and partner-to-SMIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial proton-transporting ATP synthase complex assembly grouped by SMIM4-low versus SMIM4-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM4→partner) and Y-score (partner→SMIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Mitochondrial proton-transporting ATP synthase complex assembly →	+0.092	+0.874	.002	<.001	3	9
KIDNEY	Proton-transporting ATP synthase complex assembly →	+0.092	+0.874	.002	<.001	3	9
URINARY_TRACT	Fatty acid derivative catabolic process →	+0.112	+1.181	.007	.008	2	9
LARGE_INTESTINE	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation →	+0.077	+0.880	.001	<.001	3	8
URINARY_TRACT	Positive regulation of epithelial cell differentiation →	-0.116	-1.269	<.001	<.001	2	9
URINARY_TRACT	Mesoderm formation →	-0.253	-2.107	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,410 associations by consensus.

Mitochondrial proton-transporting ATP synthase complex assembly by SMIM4 expression — KIDNEY

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