SMIM36

Across TCGA pan-cancer cohorts, SMIM36 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SMIM36 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMIM36 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SMIM36 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LAML show a favorable association.

HNSC, ACC, and DLBC are the cancer types where SMIM36 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.493	0.255	<.001	111	view →
ACC	OS	Tertile	All	0.271	0.809	<.001	72	view →
DLBC	OS	Tertile	All	0.385	0.829	.001	57	view →
KICH	OS	Tertile	All	0.191	0.875	.001	39	view →
LAML	DFS	Tertile	All	1.000	0.348	.029	30	view →
THYM	OS	Quartile	All	0.511	0.956	<.001	20	view →
LUSC	OS	Tertile	III,IV	0.553	0.740	.007	19	view →
LIHC	DFS	Quartile	II,III,IV	0.282	0.457	.005	17	view →
READ	DFS	Median	IV	0.399	0.820	.010	15	view →
STAD	DFS	Quartile	All	0.347	0.569	.018	12	view →
THCA	DFS	Tertile	All	0.228	0.824	.041	9	view →
ESCA	OS	Median	II,III,IV	0.775	0.617	.028	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SMIM36–HNSC (OS)

Open the HNSC breakdown →