SMIM35

Across TCGA cell cohorts, SMIM35 RNA expression is significantly associated with the go_rna of many other GO terms, with 722 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SMIM35-associated GO terms across cancer lineages are Lateral line system development, Regulation of neutrophil activation, and Negative regulation of TORC1 signaling. Each is linked with SMIM35 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMIM35-to-partner and partner-to-SMIM35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lateral line system development grouped by SMIM35-low versus SMIM35-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM35→partner) and Y-score (partner→SMIM35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Lateral line system development →	+0.726	+0.041	.002	.006	3	4
BLOOD_Leukemia	Regulation of neutrophil activation →	+0.117	+0.212	<.001	.007	3	4
BLOOD_Lymphoma	Negative regulation of TORC1 signaling →	+0.044	+0.496	<.001	.003	3	3
BLOOD_Lymphoma	Negative regulation of ubiquitin protein ligase activity →	-0.116	-0.400	.003	.004	2	4
LUNG_SCLC	Aorta morphogenesis →	-0.133	-0.792	<.001	.003	3	3
LUNG_SCLC	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.081	+0.699	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 722 associations by consensus.

Lateral line system development by SMIM35 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →