SMIM32

Across TCGA cell cohorts, SMIM32 RNA expression is significantly associated with the go_rna of many other GO terms, with 819 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SMIM32-associated GO terms across cancer lineages are DNA repair-dependent chromatin remodeling, Regulation of DNA-templated transcription initiation, and Positive regulation of monoatomic ion transport. Each is linked with SMIM32 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMIM32-to-partner and partner-to-SMIM32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA repair-dependent chromatin remodeling grouped by SMIM32-low versus SMIM32-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM32→partner) and Y-score (partner→SMIM32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA repair-dependent chromatin remodeling →	+0.080	+0.087	<.001	.004	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription initiation →	+0.053	+0.068	<.001	.002	3	6
UPPER_AERODIGESTIVE_TRACT	Positive regulation of monoatomic ion transport →	-0.088	-0.064	<.001	.008	3	6
LUNG_SCLC	Regulation of myoblast fusion →	+0.107	+0.468	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	Transcription preinitiation complex assembly →	+0.057	+0.085	<.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	Negative regulation of activation of membrane attack complex →	+0.169	+0.087	.004	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 819 associations by consensus.

DNA repair-dependent chromatin remodeling by SMIM32 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →