SMIM3

Across TCGA patient cohorts, SMIM3 mutation is significantly associated with the RNA expression of many other genes, with 699 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM3-associated genes across cancer lineages are LINC01758, AQP7P3, and PANDAR. Each is linked with SMIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM3-to-partner and partner-to-SMIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01758 grouped by SMIM3-low versus SMIM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM3→partner) and Y-score (partner→SMIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01758 →	+0.234	+2.456	<.001	.006	3	2
UCEC	AQP7P3 →	+0.043	+3.845	<.001	.001	3	1
UCEC	PANDAR →	+0.029	+2.577	.006	.004	3	1
CESC	FLYWCH1P1 →	+0.047	+5.103	<.001	.008	3	1
CESC	RN7SL847P →	+0.196	+5.010	<.001	.009	3	1
CESC	MIR7843 →	+0.547	+5.418	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 699 associations by consensus.

LINC01758 by SMIM3 expression — UCEC

Explore this box plot interactively →