SMIM3

Across TCGA patient cohorts, SMIM3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM3-associated genes across cancer lineages are FoxM1, INPP4B, and JNK_pT183_Y185. Each is linked with SMIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM3-to-partner and partner-to-SMIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SMIM3-low versus SMIM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM3→partner) and Y-score (partner→SMIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.260	+2.459	.037	.020	3	1
UCEC	INPP4B →	-0.353	-2.321	.023	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-3.169	.010	.019	3	1
UCEC	Notch1 →	+0.152	+3.009	.025	.019	3	1
UCEC	P-Cadherin →	-0.148	-2.999	.033	.035	3	1
UCEC	PCNA →	+0.280	+3.584	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FoxM1 by SMIM3 expression — UCEC

Explore this box plot interactively →