SMIM3

Across TCGA cell cohorts, SMIM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,844 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SMIM3-associated GO terms across cancer lineages are Regulation of proteolysis, Negative regulation of proteolysis, and Actin filament capping. Each is linked with SMIM3 in more than 9 cancer types. Because this analysis shows association rather than direction, both SMIM3-to-partner and partner-to-SMIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteolysis grouped by SMIM3-low versus SMIM3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM3→partner) and Y-score (partner→SMIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of proteolysis →	+0.105	+2.286	<.001	<.001	3	10
BONE	Negative regulation of proteolysis →	+0.186	+1.775	<.001	<.001	3	9
BONE	Actin filament capping →	+0.231	+1.959	<.001	<.001	3	9
SOFT_TISSUE	Regulation of systemic arterial blood pressure →	+0.137	+1.798	<.001	<.001	3	9
SOFT_TISSUE	Regulation of collagen metabolic process →	+0.177	+2.391	<.001	<.001	3	8
BONE	Sprouting angiogenesis →	+0.137	+2.372	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,844 associations by consensus.

Regulation of proteolysis by SMIM3 expression — SOFT_TISSUE

Explore this box plot interactively →