SMIM27

Across TCGA patient cohorts, SMIM27 protein abundance is significantly associated with the protein abundance of many other proteins, with 1,699 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SMIM27-associated proteins across cancer lineages are RBM26_S518, A1BG, and REPS1_S482. Each is linked with SMIM27 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM27-to-partner and partner-to-SMIM27 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMIM27 versus RBM26_S518 in GBM, with a Pearson correlation of -0.64.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM27→partner) and Y-score (partner→SMIM27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBM26_S518 →	-0.486	-0.732	.002	<.001	3	1
GBM	A1BG →	+0.846	+1.044	<.001	<.001	3	1
GBM	REPS1_S482 →	+0.483	+0.724	<.001	<.001	3	1
GBM	REPS1_S736 →	+0.532	+0.707	.001	.001	3	1
GBM	REPS2_S260 →	-2.286	-1.013	<.001	<.001	3	1
GBM	RFESD →	+0.881	+0.738	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,699 associations by consensus.

SMIM27 vs RBM26_S518 — GBM

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