SMIM27

Across TCGA cell cohorts, SMIM27 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,169 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SMIM27-associated GO terms across cancer lineages are Dolichol phosphate mannose biosynthetic process, Heme A biosynthetic process, and Mitochondrial electron transport, succinate to ubiquinone. Each is linked with SMIM27 in more than 6 cancer types. Because this analysis shows association rather than direction, both SMIM27-to-partner and partner-to-SMIM27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dolichol phosphate mannose biosynthetic process grouped by SMIM27-low versus SMIM27-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM27→partner) and Y-score (partner→SMIM27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Dolichol phosphate mannose biosynthetic process →	+0.100	+0.864	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Heme A biosynthetic process →	+0.059	+0.830	.008	.008	3	7
STOMACH	Mitochondrial electron transport, succinate to ubiquinone →	+0.071	+0.805	.002	.001	3	7
OVARY	Negative regulation of BMP signaling pathway →	-0.082	-0.589	.002	.002	3	7
URINARY_TRACT	Negative regulation of activin receptor signaling pathway →	-0.126	-1.085	.002	<.001	3	6
SOFT_TISSUE	Cellular response to manganese ion →	-0.081	-0.624	.003	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,169 associations by consensus.

Dolichol phosphate mannose biosynthetic process by SMIM27 expression — LARGE_INTESTINE

Explore this box plot interactively →