SMIM26

Across TCGA pan-cancer cohorts, SMIM26 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SMIM26’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SMIM26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMIM26 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, LIHC, and CHOL are the cancer types where SMIM26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMIM26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+0.723	<.001	12	view →
LIHC	Male	II,III,IV	+0.959	<.001	9	view →
CHOL	All	All	+1.330	<.001	5	view →
KIRP	All	II,III,IV	+0.481	.004	5	view →
KICH	Female	All	−0.750	<.001	4	view →
HNSC	All	III,IV	+0.364	.002	4	view →
COAD	All	All	+0.345	.004	4	view →
BLCA	All	All	+0.229	.043	3	view →
ESCA	All	All	+0.541	.008	2	view →
LUSC	All	All	+0.312	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SMIM26–KIRC

Open the KIRC breakdown →