Across TCGA patient cohorts, SMIM23 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,769 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SMIM23-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Positive regulation of DNA repair, and Positive regulation of double-strand break repair via homologous recombination. Each is linked with SMIM23 in more than 22 cancer types. Because this analysis shows association rather than direction, both SMIM23-to-partner and partner-to-SMIM23 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM23→partner) and Y-score (partner→SMIM23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of double-strand break repair →	+0.053	+0.196	<.001	<.001	3	23
STAD	Positive regulation of DNA repair →	+0.050	+0.221	<.001	<.001	3	22
STAD	Positive regulation of double-strand break repair via homologous recombination →	+0.052	+0.188	<.001	<.001	3	21
ESCA	Negative regulation of mRNA processing →	+0.058	+0.287	<.001	<.001	3	21
STAD	Protein methylation →	+0.044	+0.154	<.001	<.001	3	21
STAD	Proton motive force-driven ATP synthesis →	+0.059	+0.172	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,769 associations by consensus.

Exploration

SMIM23 survival (RNA) · tumor vs normal (RNA) · all SMIM23 data types