SMIM22

Across TCGA patient cohorts, SMIM22 protein abundance is significantly associated with the RNA expression of many other genes, with 6,768 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SMIM22-associated genes across cancer lineages are SLC44A4, RBM28, and CD37. Each is linked with SMIM22 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMIM22-to-partner and partner-to-SMIM22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMIM22 versus SLC44A4 in BRCA, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM22→partner) and Y-score (partner→SMIM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC44A4 →	+1.992	+0.524	<.001	<.001	3	4
LUAD	RBM28 →	-0.334	-0.331	<.001	<.001	3	3
OV	CD37 →	-0.910	-0.524	<.001	.001	3	3
BRCA	AGR2 →	+2.539	+0.436	<.001	<.001	3	3
OV	IL10RA →	-0.720	-0.387	<.001	.002	3	3
OV	BIN2 →	-0.621	-0.498	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,768 associations by consensus.

SMIM22 vs SLC44A4 — BRCA

Explore this scatter interactively →