Across TCGA patient cohorts, SMIM21 mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SMIM21-associated genes across cancer lineages are MIR4262, DCANP1, and OR1D4. Each is linked with SMIM21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM21-to-partner and partner-to-SMIM21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM21→partner) and Y-score (partner→SMIM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4262 →	+0.734	+7.731	<.001	.009	3	2
COAD	DCANP1 →	+0.013	+4.790	.003	.006	3	2
SKCM	OR1D4 →	+0.019	+4.147	<.001	.008	3	2
SKCM	OR5M12P →	+0.036	+4.897	<.001	.002	3	2
UCEC	OTOP1 →	+0.792	+2.713	<.001	.004	3	1
UCEC	CDT1 →	+0.924	+3.354	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

Exploration

SMIM21 survival (RNA) · tumor vs normal (RNA) · all SMIM21 data types