SMIM20

Across TCGA pan-cancer cohorts, SMIM20 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SMIM20’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SMIM20 RNA is repressed in tumor relative to normal tissue. In most cancer types SMIM20 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and CHOL are the cancer types where SMIM20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMIM20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.362	<.001	8	view →
BRCA	Female	All	−0.528	<.001	6	view →
CHOL	Female	All	+1.323	<.001	5	view →
LIHC	Male	All	+0.819	<.001	5	view →
UCEC	All	All	−0.474	.005	4	view →
KIRC	Male	All	−0.219	<.001	4	view →
KIRP	All	All	−0.260	.008	3	view →
LUSC	Male	III,IV	−0.757	.002	2	view →
BLCA	Male	III,IV	−0.641	.036	2	view →
READ	Male	All	−0.280	.013	2	view →
LUAD	All	All	+0.270	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SMIM20–THCA

Open the THCA breakdown →