SMIM2

Across TCGA patient cohorts, SMIM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,951 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible SMIM2-associated GO terms across cancer lineages are DNA methylation-dependent heterochromatin formation, Cytoskeleton-dependent intracellular transport, and Regulation of DNA methylation-dependent heterochromatin formation. Each is linked with SMIM2 in more than 17 cancer types. Because this analysis shows association rather than direction, both SMIM2-to-partner and partner-to-SMIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA methylation-dependent heterochromatin formation grouped by SMIM2-low versus SMIM2-high in KIRP.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM2→partner) and Y-score (partner→SMIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	DNA methylation-dependent heterochromatin formation →	+0.042	+0.454	<.001	<.001	3	17
UVM	Cytoskeleton-dependent intracellular transport →	+0.026	+0.243	<.001	<.001	3	16
UCS	Regulation of DNA methylation-dependent heterochromatin formation →	+0.063	+0.689	.005	.005	1	18
UVM	Negative regulation of TOR signaling →	+0.034	+0.154	<.001	<.001	3	16
UVM	TORC1 signaling →	+0.032	+0.209	<.001	<.001	3	16
STAD	Transport along microtubule →	+0.039	+0.126	<.001	.001	1	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,951 associations by consensus.

DNA methylation-dependent heterochromatin formation by SMIM2 expression — KIRP

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