Across TCGA pan-cancer cohorts, SMIM15 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMIM15 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SMIM15 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMIM15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where SMIM15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.634	0.972	.004	17	view →
CCRCC	DFS	Median	II,III,IV	0.581	0.816	.016	15	view →
HNSC	DFS	Tertile	II,III,IV	0.884	0.684	.022	11	view →
PDAC	OS	Tertile	II,III,IV	0.478	0.741	.031	6	view →
LSCC	OS	Median	All	1.000	0.948	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SMIM15 tumor-vs-normal RNA expression · all SMIM15 data types