Across TCGA patient cohorts, SMIM15 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM15-associated genes across cancer lineages are GATA6, JNK_pT183_Y185, and Notch1. Each is linked with SMIM15 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM15-to-partner and partner-to-SMIM15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM15→partner) and Y-score (partner→SMIM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.211	-2.314	.006	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.202	-3.169	.013	.018	3	1
UCEC	Notch1 →	+0.169	+3.013	.012	.018	3	1
UCEC	PKC-delta_pS664 →	-0.129	-2.990	.026	.036	3	1
UCEC	Tuberin →	+0.371	+3.169	.004	.018	3	1
UCEC	Caspase-7-cleavedD198 →	+0.875	+3.019	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

SMIM15 survival (RNA) · tumor vs normal (RNA) · all SMIM15 data types