Across TCGA patient cohorts, SMIM13 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM13-associated genes across cancer lineages are FOXO3a_pS318_S321, Ku80, and Rab25. Each is linked with SMIM13 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM13-to-partner and partner-to-SMIM13 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM13→partner) and Y-score (partner→SMIM13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.163	-3.160	.017	.019	3	1
UCEC	Ku80 →	+0.411	+3.183	.001	.010	3	1
UCEC	Rab25 →	-0.427	-3.169	.018	.020	3	1
UCEC	VHL →	-1.132	-3.169	.002	.020	3	1
UCEC	ATM →	-0.763	-3.169	.002	.020	3	1
UCEC	Caspase-8 →	-0.291	-2.973	.035	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

SMIM13 survival (RNA) · tumor vs normal (RNA) · all SMIM13 data types