SMIM12

Across TCGA patient cohorts, SMIM12 mutation is significantly associated with the RNA expression of many other genes, with 841 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM12-associated genes across cancer lineages are PRR23D2, RNU2-61P, and LINC02079. Each is linked with SMIM12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM12-to-partner and partner-to-SMIM12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23D2 grouped by SMIM12-low versus SMIM12-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM12→partner) and Y-score (partner→SMIM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRR23D2 →	+0.069	+7.954	<.001	.008	3	2
UCEC	RNU2-61P →	+0.289	+3.162	.007	.001	3	2
UCEC	LINC02079 →	+0.123	+3.226	<.001	.005	3	2
SKCM	BGLT3 →	+0.067	+5.970	<.001	.002	3	2
SKCM	MIR6752 →	+0.701	+6.199	<.001	.001	3	1
UCEC	LINC01607 →	-0.960	-3.438	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 841 associations by consensus.

PRR23D2 by SMIM12 expression — HNSC

Explore this box plot interactively →