SMIM10L1

Across TCGA cell cohorts, SMIM10L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,496 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMIM10L1-associated GO terms across cancer lineages are Adiponectin-activated signaling pathway, Regulation of centrosome cycle, and tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation. Each is linked with SMIM10L1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SMIM10L1-to-partner and partner-to-SMIM10L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adiponectin-activated signaling pathway grouped by SMIM10L1-low versus SMIM10L1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM10L1→partner) and Y-score (partner→SMIM10L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Adiponectin-activated signaling pathway →	+0.056	+0.421	.008	<.001	3	9
SOFT_TISSUE	Regulation of centrosome cycle →	+0.055	+0.411	.004	.003	3	8
URINARY_TRACT	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation →	+0.096	+0.675	.002	.001	3	8
SOFT_TISSUE	Regulation of DNA-templated transcription elongation →	+0.052	+0.583	.002	.001	3	8
BLOOD_Lymphoma	Negative regulation of gene expression, epigenetic →	+0.042	+0.571	.007	.003	2	9
BLOOD_Leukemia	Protein desumoylation →	+0.076	+0.570	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,496 associations by consensus.

Adiponectin-activated signaling pathway by SMIM10L1 expression — CNS

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