Across TCGA pan-cancer cohorts, SMIM10 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SMIM10 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SMIM10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SMIM10 expression acts as an unfavorable survival marker.

ESCA are the cancer types where SMIM10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.108	0.687	<.001	28	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SMIM10 tumor-vs-normal RNA expression · all SMIM10 data types