Across TCGA patient cohorts, SMIM10 mutation is significantly associated with the RNA expression of many other genes, with 3,149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM10-associated genes across cancer lineages are COX15, SLC25A4, and ATP5F1A. Each is linked with SMIM10 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM10-to-partner and partner-to-SMIM10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM10→partner) and Y-score (partner→SMIM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.482	+3.914	<.001	<.001	3	2
UCEC	SLC25A4 →	+0.693	+2.818	<.001	<.001	3	2
UCEC	ATP5F1A →	+0.408	+3.397	.006	.004	3	2
COAD	SKA1 →	+0.794	+3.196	<.001	.009	3	2
UCEC	CXCL13 →	+1.927	+2.807	<.001	<.001	3	2
UCEC	DHRS4 →	+0.421	+1.930	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,149 associations by consensus.

Exploration

SMIM10 survival (RNA) · tumor vs normal (RNA) · all SMIM10 data types