SMIM10

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SMIM10 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM10-associated genes across cancer lineages are GAPDH, MEK1, and PCNA. Each is linked with SMIM10 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM10-to-partner and partner-to-SMIM10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM10→partner) and Y-score (partner→SMIM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECGAPDH →+0.422+2.000.032.02932
UCECMEK1 →+0.548+3.392<.001<.00132
UCECPCNA →+0.255+2.459.001.01832
UCECPDCD4 →-0.634-2.584<.001.01032
UCECShc_pY317 →-0.194-2.807<.001.00332
COADBRD4 →+0.354+2.821.036.03532
Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

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