SMIM1

Across TCGA pan-cancer cohorts, SMIM1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SMIM1 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SMIM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SMIM1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where SMIM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.968	0.743	.013	10	view →
CCRCC	DFS	Tertile	IV	0.213	0.887	.024	8	view →
LUAD	OS	Tertile	II,III,IV	0.771	0.464	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SMIM1–UCEC (DFS)

Open the UCEC breakdown →