SMIM1

Across TCGA patient cohorts, SMIM1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,501 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SMIM1-associated genes across cancer lineages are PLK4, CEP78, and ITPKC. Each is linked with SMIM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMIM1-to-partner and partner-to-SMIM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMIM1 versus PLK4 in OV, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM1→partner) and Y-score (partner→SMIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLK4 →	-0.994	-0.735	<.001	<.001	3	3
GBM	CEP78 →	-0.704	-0.719	<.001	<.001	3	3
GBM	ITPKC →	+0.635	+0.741	.009	.002	3	3
GBM	RNA5SP335 →	-1.216	-0.795	.001	<.001	3	2
GBM	NAV2-IT1 →	-1.068	-0.715	.001	<.001	3	2
BRCA	ERVE-1 →	+1.445	+0.767	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,501 associations by consensus.

SMIM1 vs PLK4 — OV

Explore this scatter interactively →