SMILR

Across TCGA patient cohorts, SMILR RNA expression is significantly associated with the protein abundance of many other proteins, with 7,583 significant associations in total. OV shows the largest number of these associations.

The most reproducible SMILR-associated proteins across cancer lineages are CD109, MAP4K5, and P4HA2. Each is linked with SMILR in more than 5 cancer types. Because this analysis shows association rather than direction, both SMILR-to-partner and partner-to-SMILR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMILR versus CD109 in GBM, with a Pearson correlation of 0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMILR→partner) and Y-score (partner→SMILR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD109 →	+0.781	+0.735	.001	.004	3	6
OV	MAP4K5 →	+0.396	+0.819	<.001	<.001	3	5
OV	P4HA2 →	+0.631	+0.658	<.001	<.001	3	5
OV	P4HA1 →	+0.575	+0.756	<.001	.001	3	5
OV	FSCN1_S39 →	+0.718	+0.588	<.001	<.001	3	4
OV	GJA1 →	+0.720	+0.747	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,583 associations by consensus.

SMILR vs CD109 — GBM

Explore this scatter interactively →