SMG8

Across TCGA pan-cancer cohorts, SMG8 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMG8 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMG8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SMG8 expression acts as an unfavorable survival marker.

HNSC, LIHC, and CHOL are the cancer types where SMG8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.228	0.688	.004	18	view →
LIHC	OS	Median	II,III,IV	0.118	0.716	.003	12	view →
CHOL	OS	Median	All	0.154	0.793	.004	9	view →
SARC	DFS	Median	All	0.094	0.632	<.001	6	view →
LUSC	OS	Median	III,IV	0.224	0.575	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMG8–HNSC (OS)

Open the HNSC breakdown →