SMG8

Across TCGA patient cohorts, SMG8 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,231 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMG8-associated proteins across cancer lineages are COIL, BPTF, and DDX42. Each is linked with SMG8 in more than 7 cancer types. Because this analysis shows association rather than direction, both SMG8-to-partner and partner-to-SMG8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMG8 versus COIL in LSCC, with a Pearson correlation of 0.67.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG8→partner) and Y-score (partner→SMG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COIL →	+0.521	+0.579	<.001	<.001	3	8
BRCA	BPTF →	+0.303	+0.470	<.001	.008	3	6
GBM	DDX42 →	+0.394	+0.308	<.001	<.001	3	5
LSCC	SUPT6H →	+0.294	+0.583	<.001	<.001	3	5
GBM	CCNK →	+0.291	+0.184	<.001	.009	3	5
GBM	CDK7 →	+0.217	+0.214	.008	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,231 associations by consensus.

SMG8 vs COIL — LSCC

Explore this scatter interactively →