SMG8

Across TCGA cell cohorts, SMG8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,246 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMG8-associated GO terms across cancer lineages are Negative regulation of beige fat cell differentiation, DNA-templated transcription initiation, and Establishment of RNA localization. Each is linked with SMG8 in more than 15 cancer types. Because this analysis shows association rather than direction, both SMG8-to-partner and partner-to-SMG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of beige fat cell differentiation grouped by SMG8-low versus SMG8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG8→partner) and Y-score (partner→SMG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of beige fat cell differentiation →	+0.136	+0.934	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.088	+0.971	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Establishment of RNA localization →	+0.112	+0.984	.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Nucleic acid transport →	+0.110	+0.924	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	RNA transport →	+0.110	+0.924	.001	<.001	3	14
STOMACH	Epigenetic regulation of gene expression →	+0.058	+0.675	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,246 associations by consensus.

Negative regulation of beige fat cell differentiation by SMG8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →