SMG8

Across TCGA cell cohorts, SMG8 mutation is significantly associated with the RNA expression of many other genes, with 130 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMG8-associated genes across cancer lineages are HTR3D, ZSCAN1, and WNT9B. Each is linked with SMG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMG8-to-partner and partner-to-SMG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR3D grouped by SMG8-low versus SMG8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG8→partner) and Y-score (partner→SMG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HTR3D →	+0.019	+5.539	<.001	.003	3	2
OESOPHAGUS	ZSCAN1 →	+0.167	+4.392	.001	.003	3	1
OESOPHAGUS	WNT9B →	+0.018	+4.017	<.001	.007	3	1
OESOPHAGUS	RNASE8 →	+0.057	+4.857	<.001	<.001	3	1
OESOPHAGUS	MPC1L →	+0.065	+4.017	<.001	.007	3	1
OESOPHAGUS	PCDH11Y →	+0.024	+4.857	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 130 associations by consensus.

HTR3D by SMG8 expression — BLOOD_Leukemia

Explore this box plot interactively →