SMG7

Across TCGA pan-cancer cohorts, SMG7 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMG7 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMG7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SMG7 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where SMG7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.134	1.000	.008	24	view →
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	19	view →
PDAC	DFS	Quartile	All	0.285	0.528	.011	5	view →
UCEC	DFS	Tertile	III,IV	0.847	0.232	.023	4	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.759	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMG7–HNSC (OS)

Open the HNSC breakdown →